Impact of Oil Spill to Human Lung Health: Next Generation Sequencing and Mouse Model Based Analyses


Project Overview

Implementing Organization
Tulane University School of Medicine

DWH Project Funding

0

Known Leveraged Funding

0

Funding Organization

Gulf of Mexico Research Initiative (GoMRI)

Funding Program

Gulf of Mexico Research Initiative (GoMRI) Grant Program

Project Location: Multiple States

Funding Source: BP
Controlling Document: GOMRI Master Research Agreement
Year Awarded: 2017

Project Details

Project Category

Project Actions

Oil System Safety Research

Targeted Resources

Community and Human Health Human and/or Institutional Capacity

Project Description

The project uses mouse models to test the in vivo effects of oil/dispersants regarding carcinogenesis. The general hypothesis is that upon respiratory exposure to oil/dispersant there will be a higher carcinogenic potential of lung tissue in the mice. The objectives are: to profile and confirm the existence of molecular signatures of carcinogenesis through RNA-seq analysis of the mouse model (the B6 mice) treated with instilled oil/dispersants; andto determine if respiratory exposure to oil/dispersants accelerates tumorigenesis in lung tumor bearing mice (the K-Ras mice). The proposed analyses will provide compelling evidence to validate the PI’s group’s recent findings on carcinogenic potential of oil and dispersants on the lung system. The project will clarify if there are indeed harmful effects of crude oil and dispersants to human lung health for those workers involved in the oil spill cleaning process and even for those working in the presence of crude oil fumes on a daily basis. The evidence provided, if positive, will serve as a solid foundation for new legislation protecting oil industry workers and will provide the rationale for developing/using safer oil dispersants with low carcinogenicity.

Project Contact

Project Partners

None

Affiliated Institutions

Tulane University- School of Public Health & Tropical Medicine, University of South Florida


Project ID: 1029
Project Name: Impact of Oil Spill to Human Lung Health: Next Generation Sequencing and Mouse Model Based Analyses
SourceUID: 300
Latitude: 0
Longitude: 0
Country: United States of America
State or Province: FL, LA
County: Unknown Multiple Counties,
Project Category: Science
Project Action: Oil System Safety Research
Additional Project Action(s):
Additional Project Action(s):
Targeted Resource(s): Community and Human Health
Targeted Resource(s): Human and/or Institutional Capacity
Targeted Resource(s):
Anticipated Project Completion Year: 2019
Implementing Organization: Tulane University School of Medicine
Implementing Organization Type: Academic
Point of Contact – Name: Yao-Zhong Liu
Point of Contact – Phone: yliu8@tulane.edu
Point of Contact – Email: None
Other Partners: None
Affiliated Institutions: Tulane University- School of Public Health & Tropical Medicine, University of South Florida
Link: http://research.gulfresearchinitiative.org/research-awards/projects/?pid=300
Project Comments: None
Acres Acquired: 0
Close Year: 0
Close Month: 0
Close day: 0
Purchase Type: None
Landowner: None
Landowner Type: None
Purpose: None
Public Access: None
Easement Holder Name : None
Easement Holder Type: None
Secondary Easement Holder 1: None
Secondary Easement Holder 2: None
Duration: None
Term: 0
Land Restoration Acreage: 0
Aquatic Restoration Acreage: 0
Restoration Mileage: 0
Restoration Feet: 0
Additional Acreage: None
Total Dollar Amount (from all funders): 425012
DWH Funder: Gulf of Mexico Research Initiative (GoMRI)
DWH Funder Type: Private
DWH Funding Program: Gulf of Mexico Research Initiative (GoMRI) Grant Program
DWH Dollar Amount : 425012
DWH Source: BP
Fund Origin: Voluntary Agreement
Controlling Documents: GOMRI Master Research Agreement
Award Year: 2017
Award Month: 9
Total Amount Leveraged: 0